A 58-year-old man with multiple divorces and estranged relationships who exhibits signs of substance misuse could be diagnosed with?

The diagnosis of Antisocial Personality Disorder is particularly relevant for this individual given his history of multiple divorces and estranged relationships, which may suggest a pattern of unstable or problematic interpersonal relationships. Antisocial Personality Disorder is characterized by a long-standing pattern of disregard for the rights of others, along with behaviors that violate social norms and rules.

In this case, the man's substance misuse could be indicative of impulsivity and a lack of regard for consequences, both common traits in those with Antisocial Personality Disorder. Individuals with this disorder often have difficulties in maintaining relationships and may engage in behaviors that result in legal, social, or personal consequences, which aligns with the man's multiple divorces and problems with relationships.

Other disorders listed do not have the same relevance to the symptoms presented. For example, Dissociative Amnesia pertains to memory loss typically related to trauma or stress, Bulimia primarily involves issues with food and body image rather than relationship difficulties, and Panic Disorder involves recurrent unexpected panic attacks and significant anxiety about future attacks, which doesn't directly relate to the issues of substance misuse and relationship instability described in this case.